I am running 2.8.4 with a number of plugins (most are widely tested in my environments), this instance includes buddypress and KB Advanced RSS beyond those.
The site is only hours old. Its a demo so it doesn't really have to work, I am looking for experiences and ideas.
I installed KB Advanced RSS and Buddy Press just after things were working fine and later when adding more content the issue arose. I am seriously considering buddypress as the culprit due to its weight however I've not used KB Advanced RSS in MU environments either.