Hi there. :)
I already run a couple of single WP installations, and my job is webdesign and setup for clients.
I just started working for a firm with a couple of hundred members with the following requirements:
1. A single domain containing 1 website serving the firm and its members.
2. The firm needs to have a blog for themselves, and for now: another single blog where the members can post depending on their membership levels. Same theme across the blogs.
3. The firms static pages, their blog, and the memberblog needs to be available from a single menu on the firms page.
4. More memberblogs (maybe as many as 200) at the same site is likely later this year, using the same theme or optional themes. In this case the memberblogs will be listed another way, not in the main menu.
5. A single central admin environment with detailed control on each members/groups access to most functions.
Hosting is not an issue, just need to know if WPMU is the right way to go for this. Also I appologise if my English isn't quite up to spec, I'm Norwegian. ;)