My latest WPMU installation with 800+ blogs where i took these measures to reduce traffic:
--> Using lightweight themes with average loading time ~350ms
--> Plugins Multi-DB, Super Cache, Plugin Commander & a proprietary plugin for notice & event calender
--> Offload the static multimedia contents to Amazon S3
--> A proprietary widget to load RSS feed using AJAX, rather then embed the link.
This whole setup running behind load balancing server with a dedicated server for DB.
Average response time of this setup is nearly 650ms but if the with a average hit of ~18k/hour. But when the hit increase to ~30k/h the response time increase to ~850ms to ~1000ms
In my latest project I'm using WPMU for a university. There will be 1500+ blog as each department, faculty members & PhD student will have a blog.
So anybody have any suggestion to incase the performance?