There is a Sitewide blacklist to ban registrations at SiteAdmin->Options but not for comments. Each blog can build their own blacklist at Settings->Discussion.
Now that you get me thinking, I think I'd like a WPMU plugin for Sitewide comment blacklist with a textarea option at SiteAdmin->Options. Hmmm. Another day. Another plugin contest.
In the meantime, the function wp_blacklist_check from wp-includes/comment.php has a plugin hook so a quick mu-plugin tackles an emergency but isn't very elegant:
<?php
function my_site_blacklist($comment_author, $comment_author_email, $comment_author_url, $comment_content, $comment_author_IP, $comment_agent) {
if ($comment_author_email == 'cruella@deville.com') {
wp_die('No puppies here!'); // comment vanishes
}
}
add_action('wp_blacklist_check', 'my_site_blacklist', 10, 6);
?>