In menu Site Admin > Options > Menus (Enable or disable WP Backend Menus), I've deactivated the Plugins checkbox, in order to verify the effect of this option in user blogs.
Then I've tried to reactivate this option, but when I click in the Update Options menu, my browser (Firefox 2.0.0.6) tries to open the wpmu-edit.php file, instead of updating the site options.
It seems as if one the functions called by wpmu-edit.php was failing, but I haven't been able to get it.
I'm using WPMU 1.2.4 in a Linux server, with Apache 2.2 and PHP 5.1.
I've also installed Multi-user plugin Manager, version 1.2. I've uninstalled this plugin, as if it has something to do with this problem, but to no avail.