I've been asking a lot of scalability questions recently, I know...really concerned about hosting podcasts, videos, etc and want to control costs in a scalable way.
I've been thinking about Amazon S3 today -- some advantages over traditional storage, including that you get a built in CDN.
Turns out there is a plug-in for plain old WP that maps uploads onto Amazon's S3 service (over at http://tantannoodles.com/toolkit/wordpress-s3/).
Has anyone experimented with integrating S3 with their MU site? Any ideas on how close TanTan's plugin gets to MU compatibility?