I currently have my MU subdomain install working out of one location, but I want to move the core to a different subdomain, so that people could login at a different address, like this:
Main site: http://domain.org
Core/backend: http://backend.domain.com
I tried setting the WP_HOME and WP_SITE_URL in the config.php file and using .htaccess to set a subdomain. It seems that it works (content would appear), until I try to log in to the backend, then it tries to create a new subdomain with the "backend" address. MU seems to not understand that backend.domain.com is a not a new site, but rather the core file's home. The reason I wanted to do this is to move some other installs (MediaWiki, etc.) into the main site's directory.