WordPress MU

My Write Page is not Saving after Editing..any idea?

Which button are you pressing on?

What is your "Write" page?

Which version are you running?

I had a similar issue when I was running the release candidate for 1.5 which was resolved by putting this line at the bottom of your config file:

define( 'AUTOSAVE_INTERVAL', 60 );

Did you check for errors in your server or php logs?

There were issues with the object cache in previous versions but without any details, you don't give us a whole lot to go on.

Reference: http://codex.wordpress.org/Debugging_WPMU